Introduction

Welcome to the European Journal of Cancer’s Advances in Melanoma Resource Centre. The Resource Centre, edited by Prof. Reinhard Dummer, Dr. Paolo Ascierto and Dr. James Larkin, will provide you with the latest research on melanoma, including a selection of original research and review articles from some of the world’s leading journals, case studies, and other educational material. New articles will be added to the Resource Centre regularly and are openly available to our readers.

What is a Resource Centre?

A Resource Centre is a freely accessible platform, designed for healthcare professionals, that aims to increase clinical knowledge in a specific medical specialty by disseminating important new research and clinical developments more broadly. Resource Centres are all independently editorially controlled, provided in collaboration with established medical journals, hosted and managed by Elsevier, and funded by educational grants from societies and other organizations, such as medical or pharmaceutical companies.

Paper of the Month

July 2014

  • GNAQ/11 Mutations in Uveal Melanoma: Is YAP the Key to Targeted Therapy?

    Authors: Matthew G. Field, J. William Harbour

    Editor's comments:
    By Prof. Reinhard Dummer: Finally a target for the treatment of Uveal melanoma? Ocular melanomas are the most common malignancy of the eye. Approximately 50% of the effected individuals metastasize most commonly in the lever. In contrast to other melanomas ocular melanomas do not present mutations for BRAF or RAS. However they present inactivating mutations for GNAQ and GNA11, which result in increased activity of protein kinase C and the MAP kinase pathway and as now described the hippo tumor suppresser pathway including the phosphorylation of YAP. The YAP inhibitor verteporfin together with protein kinase C and MEK inhibitors might be a promising approach for this difficult to treat malignancy. References - Field MG et al., Cancer Cell 2014;25:714-715 - Feng X et al., Cancer Cell 2014;25:831-845 - Yu FX et al., Cancer Cell 2014;25:822-830

Articles

About the editor

  • Professor Reinhard G. Dummer

    Professor Dummer is Vice-Chairman of the Department of Dermatology and Head of the Skin Cancer Unit at the University Hospital of Zürich.

  • Dr. Paolo A. Ascierto

    Dr. Paolo A. Ascierto is Director at the Unit of Melanoma, Cancer Immunotherapy and Innovative Therapy, National Tumor Institute ‘Fondazione G. Pascale’, in Naples, Italy.

  • The Role of the Editor

    The editors of the Advances in Melanoma Resource Centre are appointed on the recommendation of the journal’s Editor Team, led by Editor-in-Chief, Alexander M. M. Eggermont. Professor Dummer, Dr. Ascierto and Dr. Larkin select journal articles that have been previously peer-reviewed and accepted for publication in the EJC and other oncology and dermatology journals on melanoma and related topics, building a comprehensive collection of peer-reviewed content in this area.

    The editorial independence of the resource centre is of the utmost importance.
    The journal articles and other material published on the resource centre have been selected solely by Professor Dummer and Dr. Ascierto, independently and without influence from Elsevier or the sponsor.

  • Dr. James Larkin

    Dr James Larkin, FRCP PhD is a Medical Oncologist specialising in the treatment
    of patients with cancer of the kidney and cancers of the skin, including melanoma.

Congress planner

2014

  • 3 - 6 September

    United Kingdom, Edinburgh

    The 15th World Congress on Cancers of the Skin

    More information

  • 4 - 7 September

    Singapore, Singapore

    XXII International Pigment Cell Conference

    More information

  • 18 - 21 September

    Bosnia & Herzegovina, Sarajevo

    1st Euro-Asian Melanoma Congress

    More information

  • 13 - 16 November

    Swziterland, Zurich

    Society for Melanoma Research - 2014 International Congress

    More information

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