FREE ACCESS TO THE LATEST RESEARCH


Welcome to the European Journal of Cancer’s Advances in Melanoma Resource Centre.

The Resource Centre, edited by Prof. Reinhard Dummer, Dr. Paolo Ascierto and Dr. James Larkin, will provide you with the latest research on melanoma, including a selection of original research and review articles from some of the world’s leading journals, case studies, and other educational material.

New articles will be added to the Resource Centre regularly and are openly available to our readers.

Paper of the month

  • GNAQ/11 Mutations in Uveal Melanoma: Is YAP the Key to Targeted Therapy?

    Matthew G. Field, J. William Harbour

    Cancer Cell, 6, 25, pages 714 - 715

    Editor's comments:
    By Prof. Reinhard Dummer: Finally a target for the treatment of Uveal melanoma? Ocular melanomas are the most common malignancy of the eye. Approximately 50% of the effected individuals metastasize most commonly in the lever. In contrast to other melanomas ocular melanomas do not present mutations for BRAF or RAS. However they present inactivating mutations for GNAQ and GNA11, which result in increased activity of protein kinase C and the MAP kinase pathway and as now described the hippo tumor suppresser pathway including the phosphorylation of YAP. The YAP inhibitor verteporfin together with protein kinase C and MEK inhibitors might be a promising approach for this difficult to treat malignancy.

    References

    - Field MG et al., Cancer Cell 2014;25:714-715

    - Feng X et al., Cancer Cell 2014;25:831-845

    - Yu FX et al., Cancer Cell 2014;25:822-830


Latest articles


About the editors

Professor Reinhard G. Dummer
Professor Dummer is Vice-Chairman of the Department of Dermatology and Head of the Skin Cancer Unit at the University Hospital of Zürich.

 

 


Dr. James Larkin
Dr James Larkin, FRCP PhD is a Medical Oncologist specialising in the treatment
of patients with cancer of the kidney and cancers of the skin, including melanoma



 


Dr. Paolo A. Ascierto
Dr. Paolo A. Ascierto is Director at the Unit of Melanoma, Cancer Immunotherapy and Innovative Therapy, National Tumor Institute ‘Fondazione G. Pascale’, in Naples, Italy.

 

 


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