Welcome to the European Journal of Cancer’s Advances in Melanoma Resource Centre. The Resource Centre, edited by Prof. Reinhard Dummer, Dr. Paolo Ascierto and Dr. James Larkin, will provide you with the latest research on melanoma, including a selection of original research and review articles from some of the world’s leading journals, case studies, and other educational material. New articles will be added to the Resource Centre regularly and are openly available to our readers.

What is a Resource Centre?

A Resource Centre is a freely accessible platform, designed for healthcare professionals, that aims to increase clinical knowledge in a specific medical specialty by disseminating important new research and clinical developments more broadly. Resource Centres are all independently editorially controlled, provided in collaboration with established medical journals, hosted and managed by Elsevier, and funded by educational grants from societies and other organizations, such as medical or pharmaceutical companies.

Paper of the Month

April 2014

  • Reversible and adaptive resistance to BRAF(V600E) inhibition in melanoma

    Authors: Sun C et al.

    Editor's comments:
    This is another paper focusing on BRAF resistance mechanism. It shows that BRAF inhibitors can cause a loss of melanocytic differentiation which is associated with increased EGFR and TGF-β signaling as it was predicted by the phenotype switching model (Hoek et al., Cancer Research 2008). Sox10 is a transcription factor essential for neural crest differentiation and controls melanocytic differentiation via MITF. As we are gathering more and more information about resistance mechanisms, we will be able to design therapeutic solutions hopefully.


About the editor

  • Professor Reinhard G. Dummer

    Professor Dummer is Vice-Chairman of the Department of Dermatology and Head of the Skin Cancer Unit at the University Hospital of Zürich.

  • Dr. Paolo A. Ascierto

    Dr. Paolo A. Ascierto is Director at the Unit of Melanoma, Cancer Immunotherapy and Innovative Therapy, National Tumor Institute ‘Fondazione G. Pascale’, in Naples, Italy.

  • The Role of the Editor

    The editors of the Advances in Melanoma Resource Centre are appointed on the recommendation of the journal’s Editor Team, led by Editor-in-Chief, Alexander M. M. Eggermont. Professor Dummer, Dr. Ascierto and Dr. Larkin select journal articles that have been previously peer-reviewed and accepted for publication in the EJC and other oncology and dermatology journals on melanoma and related topics, building a comprehensive collection of peer-reviewed content in this area.

    The editorial independence of the resource centre is of the utmost importance.
    The journal articles and other material published on the resource centre have been selected solely by Professor Dummer and Dr. Ascierto, independently and without influence from Elsevier or the sponsor.

  • Dr. James Larkin

    Dr James Larkin, FRCP PhD is a Medical Oncologist specialising in the treatment
    of patients with cancer of the kidney and cancers of the skin, including melanoma.

Congress planner


  • 7 - 10 May

    Lithuania, Vilnius

    10th EADO Congress - Advances in Diagnosis and Treatment of Skin Tumors

    More information

  • 30 May - 3 June

    USA, Chicago

    ASCO Annual Meeting 2014

    More information

  • 26 - 27 June

    Germany, Munich

    4th European Post-Chicago Melanoma / Skin Cancer Meeting

    More information

  • 4 - 5 July

    France, Paris

    Annual Paris Melanoma Conference

    More information

  • 3 - 6 September

    United Kingdom, Edinburgh

    The 15th World Congress on Cancers of the Skin

    More information

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